01
Melasma
The hormonally driven, sun-sensitive pigmentation that flares unpredictably and rarely responds to a single session. Cosmelan's combination of in-clinic and structured home work is well suited to it.
Mesoestetic's most considered answer to entrenched pigmentation — an in-clinic mask followed by a carefully paced home protocol across the months that follow.
Start with a conversation
At a glance
- Range
- Mesoestetic (Spanish, medical-grade)
- Format
- One in-clinic application · structured home phase
- Price
- On request — shaped at consultation
- Best for
- Melasma, post-inflammatory pigmentation, deeper sun damage
- Commitment
- Several months of careful home maintenance, paced with us
What it is
The patient, precise answer to pigmentation that hasn't moved.
Cosmelan is Mesoestetic's most considered depigmentation method. Where most pigmentation work is layered across many sessions, Cosmelan begins with a single, carefully prepared in-clinic mask — and is then carried by a structured home phase that runs across the months that follow.
The chemistry targets the enzyme that drives pigment production. Used as designed, it interrupts the cycle of over-production at multiple points and supports the skin's gradual return to a more even tone.
It is not a quick treatment. It is a careful one — and we only begin when the plan is right, your skin is prepared, and we are confident the timing suits.
What it's for
Where Cosmelan is the right answer.
Cosmelan is reserved for pigmentation that asks for more structure and patience than a peel course alone.
02
Post-inflammatory marks
The darker shadows that linger after blemishes, particularly in deeper skin tones. Cosmelan softens these gradually, with a careful regard for the skin around them.
03
Entrenched sun damage
The patchy, accumulated pigmentation that hasn't yielded to gentler protocols. Cosmelan offers a more structured route, with the home phase doing much of the quiet work.
What to expect
One careful visit. Months of quiet, paced support.
Cosmelan is not a one-and-done treatment — and not a recurring series either. It is a single protocol, carried through time.
01
The consultation
We talk through your pigment story — pattern, history, hormonal context, sun exposure, prior treatments. Cosmelan is rarely the first treatment we reach for; it earns its place only when the skin is ready and the plan suits.
02
The in-clinic application
A single visit. Cleanse, prep, and a careful, layered application of the Cosmelan mask, left on the skin to do its work. You'll leave with the mask still in place; specific timings are explained on the day.
03
The home phase
The protocol continues at home across several months, with a paced introduction of supporting maintenance products. We check in at agreed intervals; the rhythm is adjusted as your skin responds.
Frequency & rhythm
One careful protocol — not a course.
Cosmelan is structured differently from our other pigmentation work. There is one in-clinic application; the rest is paced, supported home use, with check-ins at the points where your skin is most likely to need adjustment.
After the protocol settles, ongoing maintenance is usually gentler — quiet SPF discipline, periodic supportive treatments, and the same careful eye on hormonal and seasonal triggers we use across all pigmentation work.
The most lasting Cosmelan results come from clients who pair the in-clinic application with consistent SPF, the prescribed home routine, and patience with the timeline.
Suitability
Cosmelan asks for a careful plan — and the right moment.
Cosmelan suits most skin types and tones, including deeper tones where harsher pigmentation protocols can backfire. Pregnancy, recent procedures, certain medications, and a busy summer travel schedule all change the plan — sometimes by waiting, sometimes by adjusting the timing. We'll work through everything at the consultation, and only begin when the moment is right.
You might also consider
Treatments that pair well — or come first.
Cosmelan rarely stands alone. These are the treatments most often paired with it, or considered before.
Melanostop Tran3x
A gentler, multi-active Mesoestetic protocol for pigmentation. Often the first step — or the ongoing maintenance — alongside Cosmelan.
Rice Bran AO Peel
An antioxidant-rich Lamelle peel for tired, environmentally stressed skin. Brightens without abrasion.
LED Light Therapy
A calming, light-only treatment that quietly supports collagen and reduces inflammation. A gentle finish, often after a more demanding session.
Ready to begin the conversation?
Cosmelan is a careful, considered protocol. The first appointment is a thorough conversation about your skin, your pigment story, and whether Cosmelan is the right answer right now.